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Development of 3D printing living tissue to treat arthritis
Jul 06, 2018

A challenge is to keep the right conditions of cellular materials.Since the ink contains living cells, so it is not strong enough, can't hold their shape after printing.Scientists will have to develop new solutions, one option is to use the water gel, a kind of material composed of macromolecular network.For printing, material must be able to keep the cell vitality, this need to be done at relatively low temperature water conditions and processing, which makes water gel base material as the ideal choice.

But soft enough to transfer water gel cells, they can't afford some tissue in the body subjected to mechanical load.Team to strengthen the water gel to make it more solid, like a soft steel bar and concrete, reinforced concrete, as the foundation of our body, these materials can make hydrogels are strong enough, have the effect of alternative cartilage.

Research team is using molten electrolysis of 3D printing, it will melt together, poly (caprolactone and electric field as thin fiber formation and hair.Use the micro fiber, the team created with the structure, combination of hydrogels containing cells have achieved good effect.

The combination of water gel and fiber synergy, make the strength of the composites increased by more than 50 times, while still allowing cells to produce extracellular matrix and mature as the chondroid tissue, the research team at the same time to combine different materials together, used in combination of bone and cartilage tissue substitutes.Except as a substitute for cartilage and bone loss in this way, to print cells can also help the body to repair damaged tissues.

                                                  Pathological changes of the joints

He is working to develop not only can be printed, and by changing the molecules to stimulate stem cell support and surrounded by cells, biological chip to make new cartilage, guiding them produce the right type of organization.Target is the new print after implanted stem cells can help repair damaged tissue.

The team also committed to use growth factors to stimulate the formation of new blood vessels in the lesion.They will VEGF (vascular endothelial growth factor) into our biological print organization, to promote the new bone formation in the region of the damaged bone or joint blood vessels, and bone can grow.Introducing gradient of VEGF in the organization of biological print these organizations will host blood vessels (form) is introduced into our appropriate area of the implant.

Although scientists focus on the cartilage and bone, but demand for joints may be according to their location and there were significant differences in the body.Can use special mechanical test machine to determine their rigidity and elasticity, as well as the calculation model, in order to better understand how the structure and composition of the implants in a specific environment.

There will be two main application biological after printing.First of all, as a new source of tissue and organ regenerative medicine.Secondly, as a better understanding of human disease and test the safety and efficacy of new drugs for such disease tool, the team says.

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