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Science team to develop new 3D printing method can be used to monitor the structure of the organization
Oct 10, 2018

Led by professor of chemistry at the university of Copenhagen MichaelKuhl international research team developed a new method for 3D biological printing, used for monitoring of complex structure.

Kuhl, professor with the university of technology dresden (bone metastases, joints and soft tissue) research center of the German colleagues, to use oxygen sensitive nanoparticles gel material, can be used for complex, biofilm and organization structure of 3D printing.Living cells and built-in chemical sensors.This work has just been published in the latest journal of Materials science Advanced Functional Materials.

Kuhl explains: "3D printing is a wide range of technology, used in the production of plastic, metal and other objects of biological materials.Likewise, living cells biocompatibility gel material (bioinks) can be used 3D printing, this 3D biological printing is a rapidly growing field, for example in biomedical research, structure of stem cells in 3D printing, imitating the complexity of the tissue and bone structure.This lack of growth of the cell metabolic activity in biological print structure of on-line monitoring;At present, this largely depends on the destructive sampling measurement.It has developed the patent is pending for a solution."

               In hydrogels containing green algae (chlamydomonas) of 3 d printing structure.

The team will by emitting oxygen sensitive nanoparticles implementation to the printed substrate to develop functional food chain.When the blue light stimulates the nanoparticles, and they make local??Oxygen concentration is proportional to the red glow - the more, the less red emission.Can use the camera system for printing on the biological structure of red light and oxygen distribution of imaging.This allows the online oxygen distribution and dynamics of noninvasive monitoring of its creatures can be mapped to 3D printing structure of cell growth and distribution, without damaging the sample.

Kuhl continued: "it is important to add nanoparticles will not change the mechanical properties of biopolymers such as in the printing process to avoid stress and cell death.In addition, the nanoparticles should not inhibit or interfere with the cells.We solve these challenges, because our method showed good biocompatibility, can use with micro algae and sensitive human cell lines."

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