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3D Printing Stents Help Optimize Bone Regeneration In Patients
Jan 25, 2018

Institute of harvard Wyss institute, Julius Wolff, Berlin Brandenburg regeneration therapy center and Charite musculoskeletal arm surgery center of cooperative research team together, 3d printing titanium mesh stent implants in the benefits.A recent pre-clinical study published in the journal science translational medicine said that 3D printed scaffolds did help to optimize bone regeneration in patients.


In the medical field, treatment of large bone defects or injuries remains a tricky area.People who have severe defects in their upper or lower limbs because of infection, cancer or trauma often have to have amputations because it is historically difficult to regrow or repair bone tissue that has exceeded a certain point.

An existing treatment involves making bespoke bone grafts from the patient's own bone tissue, although the success rate is not high.According to recent reports, customized 3D printing of titanium mesh scaffolds may be a potential solution, as implants promote and achieve the medical challenge of natural bone regeneration.

A team from the Charite musculoskeletal surgery center has shown that it can design and manufacture custom-made 3D printed scaffolds to treat large bone defects.Using a CT scan of the patient's skeleton, the medical team can produce a 3-d model of the defective bone.Based on this digital model, a custom-built scaffold can be modeled in 3D and then sent to medical grade titanium using laser sintering 3D printers.The resulting product is a 3D printed titanium implant with a porous scaffold structure.

It is this 3D printing structure that is critical to promoting bone regeneration because it allows doctors to fill implants with patients' bone tissue, growth factors and bone replacement materials.It is worth noting that the 3D printing grid structure has been mechanically optimized to "further strengthen the healing process".

As Dr. Anne-marie Pobloth, a veterinary surgeon at the Julius Wolff institute in Charite, explains, "my team started using computer modeling techniques to improve standard-size supports.Using large animal models, we can study the actual effects on bone regeneration.Since the process of bone regeneration is very similar to humans, we can infer that the human skeleton has healed."

So far, the Charite musculoskeletal center has implanted custom-made 3D printed bone into a total of 19 patients, all of whom have shown promising results.

The 3D printing implantation itself is characterized by honeycomb structure, which is constructed in a way that promotes and guides bone regeneration.Importantly, the researchers found that they could change the stiffness of the implant by altering the diameter of the base of the honeycomb structure, allowing them to test the effectiveness of different stiffness.

Dr Georg n. Nuda, director of the Julius Wolff center for biomechanics and skeletal muscle regeneration, said: "we believe that bone regeneration will change depending on the stiffness of the implant.Therefore, in order to study the effects of mechanical stimulation during bone regeneration, we used four test groups to receive implants with different stiffness.

The results of these tests showed that softer implants were more conducive to bone regeneration.Dr Trauma surgeon PF Philipp Schwabe explained: "even after three months, radiological evidence suggests that soft implants on the stiffness of the implant faster mechanical stimulation reaction, make the bone growth faster.

In fact, researchers have found that the biomechanical properties of 3D printed implants directly affect the amount of bone formation and the quality of the regenerative bone.From this understanding, the team is designing and producing titanium mesh scaffolds that are softer, more mechanical, and use 3D printing technology.The team says it could even be used to treat spinal, oral and maxillofacial defects.