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The New 3D Printing Can Produce Artificial Blood Vessels And Tissues
Oct 24, 2018

CU Boulder engineers developed a 3D printing, can reproduce the complicated shape of the blood vessels, and one day can be used in the production of artificial arteries and tissues.

CU Boulder method of 3D printing allows for robustness for local control of objects.It has fine grained, programmable control rigidity, allowed the researchers to simulate highly structured but must remain flexible complex vascular geometry.

"The idea is to join in the 3D structure mechanical properties of independence, to simulate the body's natural organization," the study's senior author, CU Boulder company associate professor, department of mechanical engineering Yin Xiaobo said.

"This technology allows us to create can be customized microstructure model for disease," said Yin Xiaobo.Results could one day provide people with high blood pressure and other blood vessel diseases better, more personalized treatment.

Hardening of the blood vessels is associated with cardiovascular disease, but history shows that for the activities of arteries and veins and tissue replacement challenging design solutions.In order to overcome these obstacles, CU Boulder, researchers have found a unique way to use oxygen in setting up the role of 3D printing the final form of the structure.

"Oxygen is usually a bad thing, because it is not completely cured," mechanical engineering postdoctoral researcher, said the study's lead author yong-hui ding."Here, we use a layer allows fixed oxygen permeability layers."

Through strict control of oxygen transfer and its subsequent light, researchers can freely control the object which areas curing is more hard or soft - while maintaining the overall geometry is the same.

Through the oxygen inhibition of auxiliary stereo lithography method for orthogonal programming stiffness matrix and geometric shapes.Digital projection stereo lithography schematic setup 3D printing system, in which water gel curing step by step a precursor solution by UV exposure.Illustration is a complex object of 3D printing SEM images.Scale is 500 microns.B oxygen inhibition of auxiliary print diagram, in which area physical restrictions on solidifying area and oxygen inhibition between layers.The depth of the c double bond conversion rate under different ultraviolet irradiation dose distribution.Oxygen inhibition layer thickness and the exposure dose is very weak, the relationship between the thickness of the solidified.When dose is higher than the threshold, the double bond conversion with the dose increase rapidly.3D print logo buffalo bright field optical image, has the independent design of stiffness and geometry (binary stiffness but flat surface).High optical contrast showed strong differences of crosslinking density, therefore suggests that stiffness.Scale is 200 microns.Along the dotted line in the be optical contrast (black line) and geometry (blue line) changes of quantitative display contrast (stiffness) of obvious difference, but the characteristic height changes is small (< 1%)

"This is a profound development, toward us create like healthy cells play a role of the structure of the target an encouraging first step," said yong-hui ding.